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Faculty Profile

  /  Faculty Profile

Dr Muhammad Ikram

Assistant Professor
Area of Interest: 3D cell culture, Tissue engineering and regeneration, Drug Resistance studies using bioactive materials and scaffolds, natural product research, Tumor malignancy & metastasis, and Chemoresistance, Immunobiology, Biomedical Engineering
Email: [email protected]
Phone: 0992-383591-5
 
Academics/ Degrees

  • PhD, 2018, Pusan National University, South Korea
  • MS, 2013, Pusan National University, South Korea
  • Pharm-D, 2008, University of Malakand
 
Journal Publications
1. Ikram Muhammad In Vivo Analgesic and Anti-Inflammatory Activities of the ethanolic extract from Otostegia limbata Leaves through Classic Models in Mice and Rats, Journal of Xi’an Shiyou University, Natural Science Edition, 2023
2. Shah N,Ikram Muhammad,A.J.Shah Evidence-Based Prioritization and Scoring of Genomic Loci Interacting with Pioglitazone Therapeutic Response in Diabetic Patients, Precision Medicine Communications, 2022
3. T.Khan,Ikram Muhammad,A.J.Shah LC-MS/MS based metabolomic profiling of constituents from Glochidion velutinum and its activity against prostate cancer (PC-3) cell line, Molecules, 2022
4. T.Khan,Ikram Muhammad Chemical profiling and anti-breast cancer potential of hexane fraction of Sphaeranthus indicus flowers., Tropical Journal of Pharmaceutical Research, 2022
5. Dr. Imran Ullah,Ikram Muhammad,Zia Uddin Targeted Inhibition of Protein Tyrosine Phosphatase 1B by Viscosol Ameliorates Type 2 Diabetes Pathophysiology and Histology in Diabetic Mouse Model, BioMed Research International, 2022
6. Dr. Umer Rashid,Ikram Muhammad Diclofenac derivatives as concomitant inhibitors of cholinesterase, monoamine oxidase, cyclooxygenase-2 and 5-lipoxygenase for the treatment of Alzheimer's disease: synthesis, pharmacology, toxicity and docking studies, RSC Advances, 2022
7. Muhammad Wajid Ullah ,Ikram Muhammad Dynamic Foam Characteristics during Cultivation of Arthrospira platensis, Bioengineering, 2022
8. A.J.Shah,Ikram Muhammad,T.Khan Cardioprotective Potential of Aqueous Extract of Fumaria indica on Isoproterenol-Induced Myocardial Infarction in SD Rats, Oxidative Medicine and Cellular Longevity, 2022
9. K.Rauf,Ikram Muhammad 6-Methoxyflavone and Donepezil Behavioral Plus Neurochemical Correlates in Reversing Chronic Ethanol and Withdrawal Induced Cognitive Impairment, Drug Des Devel Ther. , 2022
10. U. Rashid,Ikram Muhammad Rational design, synthesis, antiproliferative activity against MCF-7, MDA-MB-231 cells, estrogen receptors binding affinity, and computational study of indenopyrimidine-2,5-dione analogs for the treatment of breast cancer, Bioorg Med Chem Lett. , 2022
11. U. Rashid,Ikram Muhammad Structural Modification, In Vitro, In Vivo, Ex Vivo, and In Silico Exploration of Pyrimidine and Pyrrolidine Cores for Targeting Enzymes Associated with Neuroinflammation and Cholinergic Deficit in Alzheimer's Disease, ACS Chemical Neuroscience, 2021
12. U. Rashid,Ikram Muhammad,Muhammad Bilal Tufail,Muhammad Aamir Javed,Mater H. Mahnashi,Bandar A. Alyami,Abdul Sadiq Synthesis, pharmacological evaluation and Molecular modelling studies of pregnenolone derivatives as inhibitors of human dihydrofolate reductase, Steroids, 2021
13. Wasim Sajjad,Feng He,Muhammad Wajid Ullah,Ikram Muhammad,S.M.Shah,R.Khan,T.Khan,Ayesha Khalid,Guang Yang,F. Wahid Fabrication of Bacterial Cellulose-Curcumin Nanocomposite as a Novel Dressing for Partial Thickness Skin Burn, Frontiers in Bioengineering and Biotechnology , 2020
14. Ikram Muhammad Tyrosinase inhibition and anti-melanin generation effect of cinnamamide analogues, Bioorganic Chemistry , 2019
15. F. Wahid,R.Khan,Ikram Muhammad,T.Khan Fabrication and Characterization of Chitosan–Vitamin C–Lactic Acid Composite Membrane for Potential Skin Tissue Engineering, International Journal of Polymer Science, 2019
16. Ikram Muhammad Synthesis of cinnamic amide derivatives and their anti-melanogenic effect in α-MSH stimulated B16F10 melanoma cells, European Journal of Medicinal Chemistry , 2019
17. Ikram Muhammad Design, synthesis and anti-melanogenic effect of cinnamamide derivatives, Bioorganic & Medicinal Chemistry, 2018
18. Ikram Muhammad Preparation and structural characterization of surface modified microporous bacterial cellulose scaffolds: A potential material for skin regeneration applications in vitro and in vivo". , Int J Biol Macromol., 2018
19. Ikram Muhammad “Co-targeting of Tiam1/Rac1 and Notch ameliorates chemoresistance against doxorubicin in a biomimetic 3D lymphoma model” , Oncotarget. 2018; 9:2058-2075. https://doi.org/10.18632/oncotarget.23156., 2017
20. Ikram Muhammad Fish Scale Collagen Peptides Protect against CoCl 2/TNF- α-Induced Cytotoxicity and Inflammation via Inhibition of ROS, MAPK, and NF- κ B Pathways in HaCaT Cells, Oxid Med Cell Longev., 2017
21. Ikram Muhammad "Three-dimensionally microporous and highly biocompatible bacterial cellulose–gelatin composite scaffolds for tissue engineering applications" , RSC Advances, 2016
22. Ikram Muhammad "Alginate/marine collagen/agarose composite hydrogels as matrices for biomimetic 3D cell spheroid formation”, RSC Advances, 2016
23. Ikram Muhammad Engineered regenerated bacterial cellulose scaffolds for application in in vitro tissue regeneration, RSC Advacnes, 2015
24. Ikram Muhammad Marine Collagen: An Emerging Player in Biomedical applications., J Food Sci Technol. , 2015
25. Ikram Muhammad Colon-targeted delivery of budesonide using dual pH- and time-dependent polymeric nanoparticles for colitis therapy. , Drug Design, Development and Therapy, 2015
26. Ikram Muhammad Bioactive fish collagen/polycaprolactone composite nanofibrous scaffolds fabricated by electrospinning for 3D cell culture, Journal of Biotechnology , 2015
27. Ikram Muhammad Molecular characterization and expression analysis of mouse epidermal growth factor-like domain 8. , International Journal of Molecular Medicine, 2015
28. Ikram Muhammad Epidermal growth factor-like domain 8 inhibits mouse thymocyte survival and proliferation. , International Journal of Molecular Medicine, 2013
29. Ikram Muhammad Regulatory role of mouse epidermal growth factor-like protein 8 in thymic epithelial cells, Biochem Biophys Res Commun. , 2012
 
 
 
Profile/Bio

  • Dec. 2017  till May 2018: Post-Doc Researcher at Pusan National University 
  • Dec 2009 to Feb 2011: Dispensing pharmacist with international medical corps (IMC).
  • July2010 to Jan 2011: Lecturer (internee), Department of Pharmacy, University of Malakand.
 
Associations
  •  Registered pharmacist (Rph) Pharmacy Council of Pakistan
  •  Asian Federation of Biotechnology (AFOB) (Registration No. PK00033).
  •  Asia Pacific Association of Paediatric Allergy, Respirology & Immunology (APAPARI).
  • European federation of biotechnology.
  • The Korean association of Immunologist.
  • The Korean association of Anatomist
 
Research Interests

  • Designing biocompatible scaffold system for tissue engineering and drug resistance studies using bioactive materials,
  • Development of Hydrogel, micro-nanofiber, bacterial cellulose scaffolds and 3D printing,
  • T cell development, T cell activation,
  • Tumor malignancy & metastasis, and Chemoresistance)
  • Thymus regeneration
  • Liver cirrhosis recovery studies.
 
Awards

Oral Talks

  • “Co-targeting of Tiam1/Rac1 and Notch ameliorates chemoresistance against doxorubicin in a biomimetic 3D lymphoma model” Korean Association of Anatomist, Annual anatomy conferences 18-20, October 2017. BEXCO, Korea.
  • Hydrogel based 3D culture model of T cell lymphoma. Self- Damage Defence immune network Convergence Research Workshop. Immune network Pioneer Research centre, 4th workshop 2013-12-20.
  • Invitro 3D mouse T cell lymphoma model for cellular studies and Drug screening. Self- Damage Defence immune-network Convergence Research Workshop. Immune network Pioneer Research centre, 6th workshop 2014-06-20.

Poster presentations:

  • Biofunctional, AmCA Composite Hydrogels with Enhanced Transparency as Scaffolds for 3D Cell culture, Muhammad Ikram, EMBO/EMBL SYMPOSIUM 12~15 October 2016 EMBL Advance Training Centre. HEIDELBERG, GERMANY.
  • Bioactive, AmCA Composite Hydrogels with Enhanced Transparency as Scaffolds for 3D Cell culture, Muhammad Ikram, The 57 annual meeting and international symposium of korean society of life sciences: 22~23 Aug 2016. Gyeonju korea.
  • MF-1-1 enhances and thymopoitic activity of thymic epithelial cells. Muhammad Ikram, Hae Yeong Kang, Yeseon Lim, Fazli Subhan, Sun-Young baek Sik Yoon, Korean Association of Anatomist, Annual anatomy conferences 19-21, October 2016. Korea.
  • Biomimetic 3D hydrogel for the study for the study of malignancy of human prostate cancer cells. Hae Yeong Kang, Yeseon Lim, Fazli Subhan, Muhammad Ikram, Sun-Young baek Sik Yoon, Korean Association of Anatomist, Annual anatomy conferences 14-16, October, 2016. South Korea.
  • Cytoprotective and anti-inflammatory effect of MF-1-1 in HaCaT Human keratinocytes: Fazli Subhan, Muhammad Ikram, Hae Yeong Kang, Yeseon Lim, Sun-Young baek Sik Yoon, Korean Association of Anatomist, Annual anatomy conferences 14-16, October, 2016. South Korea.
  • Fabrication of a thermally cross-linked nanocomposite hydrogel for 3D cell culture. Muhammad Ikram, Fazli Subhan, Hae Yeong Kang, Yeseon Lim, Seo Young Bang, Sun-Yong Baek, Sik Yoon, the 3rd International Conference & Exhibition for Nanotechnology (NANOPIA 2016) November 17~18, 2016 Changwon Exhibition Convention Centre (CECO), Gyeongsangnam-do, Korea.
  • Fabrication and characterization of nanofibrous scaffolds with enhanced cell adhesion for 3D cell culture. Fazli Subhan, Hae Yeong Kang, Yeseon Lim, Muhammad Ikram, Seo Young Bang, Sun-Yong Baek, Sik Yoon, the 3rd International Conference & Exhibition for Nanotechnology (NANOPIA 2016) November 17~18, 2016 Changwon Exhibition Convention Centre (CECO), Gyeongsangnam-do, Korea.
  • Three dimensional culturing prostate cancer cells using fish collagen/ polycaprolactone Nanofiber scaffold as model to study epithelial to mesenchymal-transition invitro. Rira Lee, Da Jeong Choi, Hae Yeong Kang, Fazli Subhan, Muhammad Ikram, Yeseon Lim, Sun-Yong Baek, Sik Yoon Korean Association of Anatomist, Annual anatomy conferences 14-16, October, 2015. South Korea.
  • Characterization of human prostate Cancer lines in hydrogel based three dimensional in vitro model of prostate cancer. Hae Yeong Kang, Da Jeong Choi, Yeseon Lim, Fazli Subhan, Muhammad Ikram, Sun-Yong Baek, Sik Yoon Korean Association of Anatomist, Korea, Annual anatomy conferences 14-16, October, 2015. South Korea.
  • Synthesis and Characterization of a Physically Cross-Linked Hydrogel Composite for 3D Cell Culture, Muhammad Ikram, Hae Yeong Kang, Suil Shin, Fazli Subhan, Yong-Jin Na, Sik Yoon. The 2nd International Conference & Exhibition for Nanopia November 12~13, 2015 CECO (Changwon Exhibition Convention Center) Changwon Gyeongsangnam-do, Korea.
  • Modulation of the interactions of thymic epithelial cells with thymocytes by gain- and loss-of-function of mouse epidermal growth factor-like protein 8" Hee Jung Choi, Jieun Lee, Tae-Deuk Yoon, Muhammad Ikram, Fazli Subhan, Hak-Jong Choi, Sae-Ock Oh, Sun-Yong Baek, Bong-Seon Kim, Sik Yoon, BK-21 plus south Korea Research program annual conference, Pusan National University, School of Medicine, Yangsan, South Korea, Nov 23, 2012.