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Dr. Asim Ali

Dr. Asim Ali

Assistant Professor

Area of Interest: Human Genetics, Reproductive Biology

Email: [email protected]

HEC Approved PhD Supervisor

Academics / Degrees

  • Ph.D – Genetics (2019),
    Molecular and Cell Genetics Lab, School of Life Sciences, University of
    Science and Technology of China.
  • MS – Biotechnology (2014),
    Department of Biotechnology, COMSATS University Islamabad, Abbottabad
    Campus.
  • BS (Hons) – Microbiology
    (2012), Department of Microbiology, Hazara University Mansehra.

Profile / Bio

  • April, 2022 till now:
    Assistant Professor, Department of Biotechnology, COMSATS Institute of
    Information Technology, Abbottabad, Pakistan.
  • July, 2019
    to November, 2020: Postdoctoral Research Fellow at Hefei National
    Laboratory for Physical Sciences at the Microscale, The CAS Key Laboratory
    of Innate Immunity and Chronic Diseases, School of Life Sciences, CAS
    Center for Excellence in Molecular Cell Science, University of Science and
    Technology of China

Research Interests

  • Genetic Disorders
  • Reproduction Biology
  • Human Infertility
  • Cytogenetics

Awards

  • Awarded Chinese Government Scholarship for Ph.D studies in China.
  • Reviewer of the Journal “Briefings
    in Bioinformatics”.

Research Projects

  •         C11ORF80 frameshift mutation results in
    azoospermia and primary ovarian insufficiency in Pakistani consanguineous
    family- Funded by National Science Foundation of China, 2018-2021. (Co-Principal
    Investigator)
  •  
  •          RNA Splicing factor SF1 homologous frameshift
    result in spermatogenic abnormalities in human and mouse – Funded by National
    Science Foundation of China 2017-2019. (Co-Principal Investigator)   

Journal Publications

1. Menglei Yang,Qinghua Shi,<a href="MemberDetails.aspx?memberID=4826" title="Dr. Asim Ali">Ali A</a> Deficiency in DNAH12 causes male infertility by impairing DNAH1 and DNALI1 recruitment in humans and mice, Elife, 2025
2. Ahsanullah Unar,<a href="MemberDetails.aspx?memberID=4826" title="Dr. Asim Ali">Ali A</a> Determination of Electrolytes and Trace Elements in Biological Samples from Patients with Altered Semen Parameters: a Correlational Analysis, Biological Trace Element Research, 2024
3. <a href="MemberDetails.aspx?memberID=4826" title="Dr. Asim Ali">Ali A</a>,<a href="MemberDetails.aspx?memberID=126" title="Dr. Muhammad Ali">M.Ali</a>,<a href="MemberDetails.aspx?memberID=5850" title="Dr. Mian Basit Shah Kakakhel">Shah B</a> A novel NPHP4 homozygous missense variant identified in infertile brothers with multiple morphological abnormalities of the sperm flagella, Journal of Assisted Reproduction and Genetics, 2023
4. Qinghua Shi,<a href="MemberDetails.aspx?memberID=4826" title="Dr. Asim Ali">Ali A</a> Biallelic mutations in RNA-binding protein ADAD2 cause spermiogenic failure and non-obstructive azoospermia in humans, Human Reproduction Open, 2023
5. Qinghua Shi,<a href="MemberDetails.aspx?memberID=4826" title="Dr. Asim Ali">Ali A</a> Cornichon protein CNIH4 is not essential for mice gametogenesis and fertility, Developmental Biology, 2023
6. Hassan Imran Afridi,<a href="MemberDetails.aspx?memberID=4826" title="Dr. Asim Ali">Ali A</a> Effect Of Lead On The Skin And Health Of Female Dermatitis Patients Through Cosmetics., Journal of Ayub Medical College Abbottabad-Pakistan, 2023
7. Ahsanullah Unar,<a href="MemberDetails.aspx?memberID=4826" title="Dr. Asim Ali">Ali A</a> Essential trace elemental levels (Zinc, Iron and Copper) in the biological samples of referent and different types of drug abuse patients, Bioscience Research, 2022
8. <a href="MemberDetails.aspx?memberID=4826" title="Dr. Asim Ali">Ali A</a> FertilityOnline: A Straightforward Pipeline for Functional Gene Annotation and Disease Mutation Discovery, Genomics, Proteomics and Bioinformatics, 2022
9. Qinghua Shi,<a href="MemberDetails.aspx?memberID=4826" title="Dr. Asim Ali">Ali A</a> Novel Loss-of-Function Mutations in DNAH1 Displayed Different Phenotypic Spectrum in Humans and Mice, Frontiers in Endocrinology, 2021
10. <a href="MemberDetails.aspx?memberID=4826" title="Dr. Asim Ali">Ali A</a> MeiosisOnline: a manually curated database for tracking and predicting genes associated with meiosis, Frontiers in Cell and Developmental Biology, 2021
11. Qinghua Shi,<a href="MemberDetails.aspx?memberID=4826" title="Dr. Asim Ali">Ali A</a> Exonuclease 5 is dispensable for meiotic progression and male fertility in mouse, Gene, 2021
12. Suixing Fan,Qinghua Shi,<a href="MemberDetails.aspx?memberID=4826" title="Dr. Asim Ali">Ali A</a> Homozygous mutations in C14orf39/SIX6OS1 cause non-obstructive azoospermia and premature ovarian insufficiency in humans, American Journal of Human Genetics, 2021
13. Yuying Jiao,Qinghua Shi,<a href="MemberDetails.aspx?memberID=4826" title="Dr. Asim Ali">Ali A</a> A TOP6BL mutation abolishes meiotic DNA double-strand break formation and causes human infertility, Science Bulletin, 2020
14. Qinghua Shi,<a href="MemberDetails.aspx?memberID=4826" title="Dr. Asim Ali">Ali A</a> Novel loss‐of‐function variants in DNAH17 cause multiple morphological abnormalities of the sperm flagella in humans and mice, Clinical Genetics, 2020
15. Sarfraz Shafiq,<a href="MemberDetails.aspx?memberID=4826" title="Dr. Asim Ali">Ali A</a> The Interplay between Toxic and Essential Metals for Their Uptake and Translocation Is Likely Governed by DNA Methylation and Histone Deacetylation in Maize., International Journal of Molecular Sciences, 2020
16. H Muhammad,<a href="MemberDetails.aspx?memberID=4826" title="Dr. Asim Ali">Ali A</a> Diagnosis of Idiopathic Primary Infertility in a Consanguineous Infertile Family using Clinical and Molecular Cytogenetic Techniques, Genetics and Molecular Research, 2020
17. Beibei Zhang,Qinghua Shi,<a href="MemberDetails.aspx?memberID=4826" title="Dr. Asim Ali">Ali A</a> A DNAH17 missense variant causes flagella destabilization and asthenozoospermia, Journal of Experimental Medicine, 2019
18. Sarfraz Shafiq,<a href="MemberDetails.aspx?memberID=4826" title="Dr. Asim Ali">Ali A</a>,<a href="MemberDetails.aspx?memberID=491" title="Dr. Yasar Sajjad">Y.Sajjad</a> Lead, Cadmium and Zinc Phytotoxicity Alter DNA Methylation Levels to Confer Heavy Metal Tolerance in Wheat., International Journal of Molecular Sciences, 2019
19. Dong-Qing Wei,<a href="MemberDetails.aspx?memberID=4826" title="Dr. Asim Ali">Ali A</a> Immunoinformatics approaches to explore Helicobacter Pylori proteome (Virulence Factors) to design B and T cell multi-epitope subunit vaccine, Scientific Reports, 2019
20. Yubin Xie,Qinghua Shi,<a href="MemberDetails.aspx?memberID=4826" title="Dr. Asim Ali">Ali A</a> The testis-specifically expressed Dpep3 is not essential for male fertility in mice, Gene, 2019
21. Xiaohua Jiang,Qinghua Shi,<a href="MemberDetails.aspx?memberID=4826" title="Dr. Asim Ali">Ali A</a> Npat‐dependent programmed Sertoli cell proliferation is indispensable for testis cord development and germ cell mitotic arrest, FASEB Journal, 2019
22. Teka Khan,Qinghua Shi,<a href="MemberDetails.aspx?memberID=4826" title="Dr. Asim Ali">Ali A</a> Whole exome sequencing identifies a novel dominant missense mutation underlying leukonychia in a Pakistani family, Journal of Human Genetics, 2018
23. <a href="MemberDetails.aspx?memberID=4826" title="Dr. Asim Ali">Ali A</a>,Qinghua Shi IsopiRBank: a research resource for tracking piRNA isoforms, Database, 2018
24. Hao Yin,Qinghua Shi,<a href="MemberDetails.aspx?memberID=4826" title="Dr. Asim Ali">Ali A</a> A homozygous FANCM frameshift pathogenic variant causes male infertility, Genetics in Medicine, 2018
25. Qinghua Shi,<a href="MemberDetails.aspx?memberID=4826" title="Dr. Asim Ali">Ali A</a> MOF influences meiotic expansion of H2AX phosphorylation and spermatogenesis in mice, PLoS genetics, 2018
26. Manan Khan,Qinghua Shi,<a href="MemberDetails.aspx?memberID=4826" title="Dr. Asim Ali">Ali A</a> The evolutionarily conserved genes: Tex37, Ccdc73, Prss55 and Nxt2 are dispensable for fertility in mice, Scientific Reports, 2018
27. Yu-Sheng Liu,<a href="MemberDetails.aspx?memberID=4826" title="Dr. Asim Ali">Ali A</a> Feasibility analysis of treating severe intrauterine adhesions by transplanting menstrual blood-derived stem cells, International journal of molecular medicine, 2018
28. <a href="MemberDetails.aspx?memberID=135" title="Dr. Rafiq Ahmad">R.Ahmad</a>,<a href="MemberDetails.aspx?memberID=4826" title="Dr. Asim Ali">Ali A</a> Cystatin genes identification and antibacterial activity in medicinal plants used against clinical pathogens., SYLWAN, 2018
29. Qinghua Shi,<a href="MemberDetails.aspx?memberID=4826" title="Dr. Asim Ali">Ali A</a> Anaconda: AN automated pipeline for somatic COpy Number variation Detection and Annotation from tumor exome sequencing data, BMC bioinformatics, 2017
30. Shi Yin,Qinghua Shi,<a href="MemberDetails.aspx?memberID=4826" title="Dr. Asim Ali">Ali A</a> Histone acetyltransferase KAT8 is essential for mouse oocyte development by regulating reactive oxygen species levels, Development, 2017
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