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Dr Zia Uddin

Dr Zia Uddin

Associate Professor

Area of Interest: Pharmacognosy/ Drugs discovery from natural products

Email: [email protected]

HEC Approved PhD Supervisor

Academics / Degrees

  • Postdoc, Institute of Agriculture and Life Science,
    GNU, South Korea, 2018.
  • Ph.D, Gyeongsang National University, South Korea,
    2017.
  • M.S, Gyeongsang National University, South Korea,
    2014.
  • Pharm.D, University of Malakand, KPK, Pakistan,
    2010.

Profile / Bio

  • July.2018 till now: Assistant Professor, Department of
    Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Pakistan
  • August.2017 to June. 2018: Postdoctoral Research Fellow,
    Institute of Agriculture and Life Science, GNU, South Korea.
  • March. 2015 to July. 2017: Researcher, IALS, Gyeongsang
    National University, South Korea.

 

Research Interests

  • Activity guided fractionation and purification of targeted active constituents.
  • Structural characterization and complete identification of lead molecules.
  • Evaluation of biological activities on enzymes based assays.
  • Structure activity relationship (SAR) study of potent molecules.
  • Enzymes inhibition and their detailed Kinetic study, mechanisticbehaviors, and enzyme-inhibitor interaction.
  • Quantitative and qualitative analysis of secondary metabolites.
  • Metabolite farming, monitoring the flow of secondary metabolites during different growth stages.

Journal Publications

1. <a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> Targeting NLRP3 and AIM2 signaling pathways by Viscosol alleviates metabolic dysregulations induced inflammatory responses in diabetic neuro- and nephropathy: An in silico and in vivo study, PlosOne, 2025
2. <a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> Acute Toxicity and Antihyperlipidemic Effects of Syringaldehyde with Downregulation of SREBP‑2 Gene Expression in Rats, ACS Omega, 2025
3. <a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> UHPLC-QTOF-MS-Based Metabolic Profiling, Estimation of Antioxidants and Anticancer Potential Assessment of Dicliptera bupleuroides Nees by Caspase Activation, and ROS and MMP Evaluation by Using Fluorescence , Microscopy Research & Technique, 2025
4. <a href="MemberDetails.aspx?memberID=744" title="Dr. Muhammad Ikram (Secretory) ">Ikram Muhammad</a>,<a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a>,<a href="MemberDetails.aspx?memberID=657" title="Dr. Muhammad Imran Amirzada">I.Amirzada</a>,<a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a>,<a href="MemberDetails.aspx?memberID=641" title="Dr. Umer Rashid ">U. Rashid</a> Syringic acid improves cyclophosphamide-induced immunosuppression in a mouse model., Biochemical and Biophysical Research Communications' 2024 November, 2024
5. <a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> Streptomyces sp. from desert soil as a biofactory for antioxidants with radical scavenging and iron chelating potential , BMC Microbiology, 2024
6. <a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> Syringic acid improves cyclophosphamide-induced immunosuppression in a mouse model, Biochemical and Biophysical Research Communications, 2024
7. <a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> Integrative Investigation and Prioritization of Candidate Genes PTGS-2 and VEGF: Unveiling their Interaction with Celecoxib for Targeted Therapeutic Applications. , Precision Medicine Communications, 2023
8. <a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> Assessment of Human Interleukin-24 Expression in Thalassemic Patients and Investigation of Current Prescription Pattern in Thalassemia. , Currents In Pharmaceutical Research, 2023
9. <a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> Evidence-Based Prioritization and Scoring of Genomic Loci Interacting with Pioglitazone Therapeutic Response in Diabetic Patients, Precision MedicineCommunications, , 2022
10. Dr. Imran Ullah,<a href="MemberDetails.aspx?memberID=744" title="Dr. Muhammad Ikram (Secretory) ">Ikram Muhammad</a>,<a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> Targeted Inhibition of Protein Tyrosine Phosphatase 1B by Viscosol Ameliorates Type 2 Diabetes Pathophysiology and Histology in Diabetic Mouse Model, BioMed Research International, 2022
11. <a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> Hesperetin activated SIRT1 neutralizes cadmium effects on the early bovine embryo development, Theriogenology, 2022
12. <a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> PEGylated-Protamine Letrozole Nanoparticles: A Promising Strategy to Combat MCF-7 Human Breast Cancer Cells, BioMed Research International, 2022
13. <a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> Carveol a Naturally-Derived Potent and Emerging Nrf2 Activator Protects Against Acetaminophen-Induced Hepatotoxicity, Frontiers in Pharmacology, 2021
14. <a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a>,<a href="MemberDetails.aspx?memberID=641" title="Dr. Umer Rashid ">U. Rashid</a> Evaluation of Cholinesterase Inhibitory Potential of Different Genotypes of Ziziphus nummularia, Their HPLC-UV, and Molecular Docking Analysis, Molecules , 2020
15. <a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> Evaluation of neuroprotective and antiamnesic effects of Elaeagnus umbellata Thunb. On scopolamine-induced memory impairment in mice, BMC Complementary Medicine and Therapies, 2020
16. <a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> Hepatoprotective effects of melatonin and celecoxib against ethanol-induced hepatotoxicity in rats, Immunopharmacology and Immunotoxicology, 2020
17. <a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> Highly potent bacterial neuraminidase inhibitors, chromenone derivatives from Flemingia philippinensis, International Journal of Biological Macromolecules, 2019
18. <a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> Bacterial neuraminidase inhibition by phenolic compounds from Usnea longissima, South African Journal of Botany , 2019
19. <a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> Antioxidant Activities of Phenolic Metabolites from Flemingia philippinensis Merr. et Rolfe and Their Application to DNA Damage Protection, Molecules, 2018
20. <a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> Competitive Neutrophil Elastase Inhibitory Isoflavones from the Roots of Flemingia philippinensis, Bioorganic Chemistry, 2018
21. <a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> Isolation and Characterization of Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitory Polyphenolic Compounds From Dodonaea viscosa and Their Kinetic Analysis, Frontiers in Chemistry, 2018
22. <a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> Caged xanthones displaying protein tyrosine phosphatase 1B (PTP1B) inhibition from Cratoxylum cochinchinense, Bioorganic Chemistry, 2018
23. <a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> Inhibition of protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase by xanthones from Cratoxylum cochinchinense, and their kinetic characterization, Bioorganic & Medicinal Chemistry, 2018
24. <a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> Phytochemical profile and angiotensin I converting enzyme (ACE) inhibitory activity of Limonium michelsonii Lincz, Journal of Natural Medicen, 2017
25. <a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> Polydatin improves the developmental competence of bovine embryos in vitro via induction of sirtuin 1 (Sirt1), Reproduction, Fertility and Development, 2017
26. <a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> 2-Methoxystypandrone improves in vitro-produced bovine embryo quality through inhibition of IKBKB, Theriogenology, 2017
27. <a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> Inhibition of protein tyrosine phosphatase (PTP1B) and a-glucosidase by geranylated flavonoids from Paulownia tomentosa, Journal of Enzyme inhibition and Medicinal Chemistry, 2017
28. <a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> Visconata: A rare flavonol having long chain fatty acid from Dodonaea viscosa which inhibits Human neutrophil elastase (HNE), Tetrahedron Letters, 2017
29. <a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> Prenylated Flavonoids from Epimedium koreanum Nakai and their Human Neutrophil Elastase Inhibitory Effects, Records of Natural Products, 2017
30. <a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> Competitive protein tyrosine phosphatase 1B (PTP1B) inhibitors, prenylated caged xanthones from Garcinia hanburyi and their inhibitory mechanism., Bioorganic & Medicinal Chemistry, 2017
31. <a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> Potent bacterial neuraminidase inhibitors, anthraquinone glucosides from Polygonum cuspidatum and their inhibitory mechanism., Journal of Ethnopharmacology, 2016
32. <a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> Ethylene Induced a High Accumulation of Dietary Isoflavones and Expression of Isoflavonoid Biosynthetic Genes in Soybean (Glycine max) Leaves, Journal of Agricultural and Food Chemistry, 2016
33. <a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> Human Neutrophil Elastase Inhibitory Alkaloids from Chelidonium majus L., Journal of Applied Biological Chemistry, 2015

Conference Publications

1. <a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> Investigation of Anti-diabetic Potential of Cedrela serrata Leaves Extract , , 2019
2. <a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> Evaluation of anti-diabetic potential and secondary metabolites profiling of Cedrela serrata leaves, , 2019
3. <a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> Evaluation of anti-diabetic potential of Dodonaea viscosa by inhibiting protein tyrosine phosphatase 1B (PTP1B) enzyme and its kinetic analysis, , 2019
4. <a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> Discovery of a novel flavonol having long chain fatty acid from Dodonaea viscosa which inhibits Human neutrophil elastase (HNE), , 2019

Books and Book Chapters

1. <a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> Cancer Biomarkers in Diagnosis and Therapeutics, , 2022
2. <a href="MemberDetails.aspx?memberID=744" title="Dr. Muhammad Ikram (Secretory) ">Ikram Muhammad</a>,<a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a> Biomarkers in Cancer Survival and Drug Resistance, , 2022
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