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Dr Nabi Shah

Dr Nabi Shah

Tenured Associate Professor

Area of Interest: Pharmacology (Pharmacoepidemiology, Pharmacogenetics and Pharmacogenomics)  

Email: [email protected]

Academics / Degrees

Postdoctoral Studies

Pat McPherson Center for Pharmacogenomics & Pharmacogenetics, Medical Research Institute Ninewells Hospital & Medical School, University of Dundee, UK, 2014-2016

M.Phil/Ph.D

Pharmacology, Faculty of Pharmacy, University of Karachi, Pakistan, 2013

B.Pharmacy

Faculty of Pharmacy, University of Karachi, Pakistan, 2006

Profile / Bio

Oct 2013-To date       Assistant Professor  of Pharmacology

COMSATS Institute of Information Technology, Department of Pharmacy, Abbottabad campus, Pakistan

 

2016-To date              Honorary Associate Staff (Postdoctoral Research Assistant)

Pat McPherson Center for Pharmacogenomics & Pharmacogenetics, Medical Research Institute, Ninewells Hospital & Medical School, University of Dundee, Scotland, UK

2014-2016                   Postdoctoral Research Assistant

Pat McPherson Center for Pharmacogenomics & Pharmacogenetics, Medical Research Institute, Ninewells Hospital & Medical School, University of Dundee, Scotland, UK

2009- 2013                  Research Officer

Center for Non Communicable Diseases, Karachi (June, 2009-June 2013)

 

2011-2012                   Visiting Scholar

Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge:(October, 2011- March, 2012)

 

2006-2009                   Research Associate

Department of Biological and Biomedical Sciences (DBBS), Aga Khan University Karachi, Karachi. Pakistan. (September, 2006- May, 2009)

Associations

I am working on large-scale leading genetic associations’ studies of South Asia (Pakistan)and European population such as, Pakistan Risk of Myocardial Infarction Study (PROMIS), Risk Assessment of Cerebrovascular Events (RACE), Pakistan Type-2 Diabetes Study, and 1000 Genome Pakistan, andGenetics of Diabetes and Audit Research Tayside Study(GoDARTS) and GOSHARE.

Research Interests

My expertise ranges from basic pharmacological techniques to the specialization in analysis for disease-gene association studies and Pharmacogenomics associations in experimental and observational studies including genome-wide association studies (GWAS), genome wide association meta-analysis (GWAMA). My major scientific interests center on identifying genetic architecture of complex human diseases and traits (e.g. cardiovascular diseases and drug response). My research focus is sources of inter-patient variability in drug response, particularly cardiovascular drug pharmacogenomics and disease-gene association that may be relevant to pharmacogenomics, and the influence of race/ethnicity on drug response and pharmacogenomics. The majority of my research centers around the pharmacogenomics of antihypertensive and antidiabetic drugs.

Journal Publications

1. <a href="MemberDetails.aspx?memberID=197" title="Prof. Dr. Abdul Jabbar Shah ">A.J.Shah</a>,<a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> Vanillic acid reverses castor oil-induced diarrhea in BALB/c mice through cholinergic and calcium channel blocking effects, Pakistan Journal of Pharmaceutical Sciences , 2026
2. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a>,<a href="MemberDetails.aspx?memberID=744" title="Dr. Muhammad Ikram (Secretory) ">Ikram Muhammad</a> Toxicological profiling and diuretic potential of arbutin via aldosterone synthase gene inhibition, Life Sciences , 2025
3. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a>,<a href="MemberDetails.aspx?memberID=744" title="Dr. Muhammad Ikram (Secretory) ">Ikram Muhammad</a> Acute Toxicity and Antihyperlipidemic Effects of Syringaldehyde with Downregulation of SREBP-2 Gene Expression in Rats, ACS Omega , 2025
4. <a href="MemberDetails.aspx?memberID=197" title="Prof. Dr. Abdul Jabbar Shah ">A.J.Shah</a>,<a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a>,<a href="MemberDetails.aspx?memberID=744" title="Dr. Muhammad Ikram (Secretory) ">Ikram Muhammad</a> Gentisic acid protects Sprague-Dawley rats from myocardial infarction through reversing electrocardiographical, biochemical and histopathological abnormalities, Biochem Biophys Res Commun , 2025
5. <a href="MemberDetails.aspx?memberID=744" title="Dr. Muhammad Ikram (Secretory) ">Ikram Muhammad</a>,<a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a>,<a href="MemberDetails.aspx?memberID=657" title="Dr. Muhammad Imran Amirzada">I.Amirzada</a>,<a href="MemberDetails.aspx?memberID=743" title="Dr. Zia Uddin">Zia Uddin</a>,<a href="MemberDetails.aspx?memberID=641" title="Dr. Umer Rashid ">U. Rashid</a> Syringic acid improves cyclophosphamide-induced immunosuppression in a mouse model., Biochemical and Biophysical Research Communications' 2024 November, 2024
6. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a>,<a href="MemberDetails.aspx?memberID=197" title="Prof. Dr. Abdul Jabbar Shah ">A.J.Shah</a> Diuretic effects of Hecogenin and Hecogenin acetate via aldosterone synthase inhibition, Saudi Pharmaceutical Journal' 10 July, 2024
7. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> Prioritization of Kidney Cell Types Highlights Myofibroblast Cells in Regulating Human Blood Pressure, Kidney International Reports , 2024
8. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> Integration of genetic fine-mapping and multi-omics data reveals candidate effector genes for hypertension, American Journal of Human Genetics , 2023
9. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> Observational and Genetic Evidence for Bidirectional Effects Between Red Blood Cell Traits and Diastolic Blood Pressure, American Journal of Hypertension, 2023
10. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> Genetic insights into resting heart rate and its role in cardiovascular disease , Nature Communications, 2023
11. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity, Stroke, 2023
12. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a>,<a href="MemberDetails.aspx?memberID=744" title="Dr. Muhammad Ikram (Secretory) ">Ikram Muhammad</a>,<a href="MemberDetails.aspx?memberID=197" title="Prof. Dr. Abdul Jabbar Shah ">A.J.Shah</a> Evidence-Based Prioritization and Scoring of Genomic Loci Interacting with Pioglitazone Therapeutic Response in Diabetic Patients, Precision Medicine Communications, 2022
13. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> PEGylated Protamine Letrozole Nanoparticles: A Promising Strategy to Combat Human Breast Cancer via MCF-7 Cell Lines, 'BioMed Research International' June 2022, 2022
14. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> Analyzing human knockouts to validate GPR151 as a therapeutic target for reduction of body mass index, 'PLoS Genetics' April 2022, 2022
15. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> Cardiovascular Risk Factors and MRI Markers of Cerebral Small Vessel Disease: A Mendelian Randomization Study, Neurology, 2022
16. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> Evidence-Based Assessment and Prioritization of Candidate Genes (PTGS-2 and CYP2C9) Interacting with Celecoxib, 2020, 2020
17. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals., Journal Of The American College Of Cardiology , 2019
18. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> An Unbiased Lipid Phenotyping Approach To Study the Genetic Determinants of Lipids and Their Association with Coronary Heart Disease Risk Factors., Journal of Proteome Research, 2019
19. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> Trans-ethnic association study of blood pressure determinants in over 750,000 individuals., Nature Genetics, 2019 Jan, 2019
20. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits., Nature Genetics, 2018, 2018
21. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> The burden and high prevalence of hypertension in Pakistani adolescents: a meta-analysis of the published studies, Archives of Public Health, 2018
22. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease., Nature Genetics. 2017 Sep 4. doi: 10.1038/ng.3943. [Epub ahead of print], 2017
23. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney, Hypertension. doi: 10.1161/HYPERTENSIONAHA.117.09438. [Epub ahead of print] , 2017
24. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> Discovery of novel heart rate-associated loci using the Exome Chip., Human Molecular Genetics. 2017 Apr 3. doi: 10.1093/hmg/ddx113. [Epub ahead of print], 2017
25. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk, Nature Genetics, 2017
26. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> Causal assessment of serum urate levels in cardiometabolic diseases through a Mendelian Randomization study., Journal of the American College of Cardiology , 2016, 2016
27. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> A novel interaction between the FLJ33534 locus and smoking in obesity: a genome-wide study of 14 131 Pakistani adults, International Journal of Obesity, 2016
28. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> Physical activity, smoking, and genetic predisposition to obesity in people from Pakistan: the PROMIS study., BMC Medical Genetics, 2015
29. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> Frequency and determinants of intracranial atherosclerotic stroke in urban Pakistan., Journal of Stroke and Cerebrovascular Diseases, 2014, 2014
30. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> Functional nature of the spasmolytic effect, phytochemical composition and acute toxicity studies on Sauromatum guttatum. , Bangladesh Journal Pharmacology, 2014, 2014
31. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. , Nature Genetics, March 2014, 2014
32. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> Stroke radiology and distinguishing characteristics of intracranial atherosclerotic disease in native South Asian Pakistanis. , International Journal of Stroke, October 2012, 2013
33. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> Circadian gene variants and susceptibility to type 2 diabetes: a pilot study. , Plos One, 2012, 2012
34. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> Consortium. Large-scale gene-centric analysis identifies novel variants for coronary artery disease. , PLoS Genetics. Sep 2011, 2011
35. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci., Nature Genetics, 2011, 2011
36. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease., Nature Genetics, 2011, 2011
37. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> Genetic determinants of major blood lipids in Pakistanis compared with Europeans., Circulation Cardiovascular Genetics. 2010, 2010
38. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> Association of the 9p21.3 locus with risk of first-ever myocardial infarction in Pakistanis: case-control study in South Asia and updated meta-analysis of Europeans., Arteriosclerosis, Thrombosis, and Vascular Biology, 2010, 2010
39. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> The Karachi intracranial stenosis study (KISS) Protocol: an urban multicenter case-control investigation reporting the clinical, radiologic and biochemical associations of intracranial stenosis in Pakistan., BMC Neurology, 2009, 2009
40. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> The Pakistan Risk of Myocardial Infarction Study: a resource for the study of genetic, lifestyle and other determinants of myocardial infarction in South Asia., European Journal of Epidemiology, 2009, 2009

Conference Publications

1. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> PPARG and CYP2C8 Genes Interacting with Pioglitazone Response in Type 2 Diabetes Patients, , 2020
2. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> Nephroprotective Activity of Astragalus Sarcocolla in Oxidative Stress induced Renal Toxicity , , 2020
3. <a href="MemberDetails.aspx?memberID=381" title="Dr. Nabi Shah (Group Leader)">Shah N</a> ROLE OF GENETICS AND GENOMICS IN BLOOD PRESSURE REGULATION, , 2019